Monocytopenia, morphological anomalies and hyperinflammation characterise severe COVID-19 in type 2 diabetes

ABSTRACT: Early in the COVID-19 pandemic, type 2 diabetes (T2D) was marked as a risk-factor for severe disease. Inflammation is central to the aetiology of both conditions where immune responses influence disease course. Identifying at-risk groups through immuno-inflammatory signatures can direct personalised care and help develop potential targets for precision therapy. This observational study characterised immunophenotypic variation associated with COVID-19 severity in T2D. Broad-spectrum immunophenotyping quantified 15 leukocyte populations in circulation from a cohort of 45 hospitalised COVID-19 patients with and without T2D. Lymphocytopenia, of CD8+ lymphocytes, was associated with severe COVID-19 and intensive care admission in non-diabetic and T2D patients. A morphological anomaly of increas

SUBMITTER: Fawaz Alzaid 

PROVIDER: S-SCDT-EMM-2020-13038 | biostudies-other |

REPOSITORIES: biostudies-other