The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells

ABSTRACT: Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programs are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible piggyBac (PB) transposon mutagenesis screen, we have shown that overexpression of the transcriptional factor nuclear factor IB (NFIB) alone is sufficient to enhance primary mammary tumour growth and lung metastatic colonization. Mechanistically and functionally, NFIB directly increases expression of the oxidoreductase ERO1A, which enhances HIF1?-VEGFA-mediated angiogenesis and colonization, the last and fatal step of the metastatic cascade. NFIB is thus clinically relevant: it is preferentially expressed in the poor-prognostic group of basal-like breast cance

SUBMITTER: Dr. Federica Zilli 

PROVIDER: S-SCDT-EMM-2020-13162 | biostudies-other |

REPOSITORIES: biostudies-other