Antioxidant nanozyme counteracts HIV-1 by modulating intracellular redox potential

ABSTRACT: Reactive oxygen species (ROS) regulates the replication of human immunodeficiency virus (HIV-1) during infection. However, the application of this knowledge to develop therapeutic strategies remained unsuccessful due to the harmful consequences of manipulating cellular antioxidant systems. Here, we show that vanadium pentoxide (V2O5) nanosheets functionally mimic natural glutathione peroxidase activity to mitigate ROS associated with HIV-1 infection without adversely affecting cellular physiology. Using genetic reporters of glutathione redox potential and hydrogen peroxide, we showed that V2O5-nanosheets catalyze ROS neutralization in HIV-1 infected cells and uniformly block viral reactivation and replication. Mechanistically, V2O5-nanosheets suppressed HIV-1 by affecting the expression of

SUBMITTER: Ms. Shalini Singh 

PROVIDER: S-SCDT-EMM-2020-13314P | biostudies-other |

REPOSITORIES: biostudies-other