The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis

ABSTRACT: The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune-suppressive and cancer-permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Despite their presence, T cell-directed therapies fail to elicit effective anti-tumor immune responses. Here we seek to evaluate the applicability of radio-immunotherapy to modulate tumor immunity and overcome inhibitory effects that diminish anti-cancer activity. Radiotherapy-induced immune modulation resulted in an increase in cytotoxic T cell numbers and prevented the induction of lymphocyte-mediated immune suppression. Radio-immunotherapy led to significantly improved tumor control with prolonged median survival in experimental breast-to-brain metastasis. However

SUBMITTER: Dr. Lisa Sevenich 

PROVIDER: S-SCDT-EMM-2020-13412 | biostudies-other |

REPOSITORIES: biostudies-other