Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration

ABSTRACT: The mechanisms of organ size control remain poorly understood. A key question is how cells collectively sense the overall status of a tissue. We addressed this problem focusing on mouse liver regeneration. Using digital tissue reconstruction and quantitative image analysis, we found that the apical surface of hepatocytes forming the bile canalicular network expands concomitant with an increase of F-actin and phospho-Myosin, to compensate an overload of bile acids. These changes are sensed by the Hippo transcriptional co-activator YAP, which localizes to apical F-actin-rich regions and translocates to the nucleus in dependence of the integrity of the actin cytoskeleton. This mechanism tolerates moderate bile acid fluctuations under tissue homeostasis, but activates YAP in response to sustai

SUBMITTER: Kirstin Meyer 

PROVIDER: S-SCDT-MSB-19-8985 | biostudies-other |

REPOSITORIES: biostudies-other