Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

ABSTRACT: Clinical immunity to P. falciparum malaria is non-sterilizing, with adults often experiencing asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial and required to help maintain clinical immunity. Emerging views suggest that these infections are detrimental and constitute a parasite reservoir that perpetuates transmission. To define the impact of asymptomatic malaria, we pursued a systems approach integrating antibody responses, mass cytometry, and transcriptional profiling of individuals experiencing symptomatic and asymptomatic P. falciparum infection. Defined populations of classical and atypical memory B cells and a TH2 cell bias were associated with reduced risk of clinical malaria. Despite these protective responses, asymptomatic malaria featured an

SUBMITTER: Ms. Stephanie, I Studniberg 

PROVIDER: S-SCDT-MSB-2021-10824 | biostudies-other |

REPOSITORIES: biostudies-other