Cells of the adult human heart

ABSTRACT: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart?s molecular processes. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavor. Here, using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes, we characterise six anatomical adult heart regions (left/right atria and ventricles, apex, interventricular septum). Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, revealing distinct atrial and ventricular subsets with diverse developmental origins and specialized properties. We define the complexity of the cardiac vascul

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Monika Litviňuková 

PROVIDER: S-SUBS13 | biostudies-other |

SECONDARY ACCESSION(S): SAMEA7249626

REPOSITORIES: biostudies-other