Integrative computational analysis of the substantia nigra pars compacta and the locus coeruleus

ABSTRACT: The cells of the human brain show levels of functional specialization arguably unparalleled in biology. The recent advent of high-throughput, genome-wide assays to measure expression in individual cells offers an opportunity to characterize cellular variation in the human brain in a comprehensive, unbiased manner, providing a foundation for a brain-wide cell atlas. Crucial to the success of an atlas-scale project, however, is delivering a classification framework that is robust to variation across individuals, age and gender. Developing experimental and analytical tools that parse core, shared molecular signatures from inter-individual variation is therefore critically needed. The first step towards building these important tools is the acquisition and analysis of datasets from tissues kno

SUBMITTER: Evan Macosko 

PROVIDER: S-SUBS14 | biostudies-other |

SECONDARY ACCESSION(S): SAMEA7283910

REPOSITORIES: biostudies-other