Tacrolimus-induced nephrotoxicity in proximal tubule cells sorted from iPSC-derived kidney organoids

ABSTRACT: Tacrolimus (TAC) is a first-line immunosuppressant used to prevent rejection after solid-organ transplantation, yet its clinical utility is limited by nephrotoxicity, which can progress to irreversible kidney injury or graft loss. The molecular mechanisms underlying TAC-induced nephrotoxicity remain insufficiently understood. Here, we systematically assessed TAC responses across human in vitro nephron model: proximal tubule cells sorted from iPSC-derived kidney organoids.

ORGANISM(S): Homo sapiens

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PROVIDER: S-VHPS24 | biostudies-other |

REPOSITORIES: biostudies-other