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Genome binding profile of the conserved CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells


ABSTRACT: The CSB-PGBD3 fusion protein arose over 43 million years ago when a 2.5 kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates. The CSB-PGBD3 fusion protein binds internally-deleted PGBD3 elements called MER85s in vitro, and induces a strong interferon-like innate antiviral immune response when expressed in CSB-null UVSS1KO cells. To explore the connection between DNA binding and gene expression changes induced by CSB-PGBD3, we investigated the genome-wide DNA binding profile of the fusion protein. 1 ChIP sample and 1 unenriched input control from the same crosslinked chromatin pool

SUBMITTER: Lucas Gray 

PROVIDER: E-GEOD-37919 | BioStudies | 2012-07-10

SECONDARY ACCESSION(S): SRP013023

REPOSITORIES: biostudies

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