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Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF


ABSTRACT: We evaluated two matched human cell lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment Analysis of microarray data identified a highly significant induction of oxidative phosphorylation gene set in MITF expressing cells compared to control cells.

ORGANISM(S): Homo sapiens

PROVIDER: E-GEOD-38007 | BioStudies |

REPOSITORIES: biostudies

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