Dataset Information


Differentially expressed genes between oncogene-transformed and non-transformed fetal liver progenitor cells

ABSTRACT: The activation of different oncogenic signals may primarily contribute to the heterogeneity of cancer cells. However, the exact mechanisms underlying different oncogenic transformation are still unclear. We used the c-Myc, H-Ras and Akt transformed liver cell model to define mRNA expression profiles in the non-transformed and the three types of oncogene-transformed cells Purified p53-/- mouse fetal liver progenitor cells were transformed by three oncogenic genetic factors, c-Myc, H-RasV12 and myristoylated-AKT1(myr-Akt). The gene expression profilings of transformed cells and control cells were analyzed through microarray.

ORGANISM(S): Mus musculus

PROVIDER: E-GEOD-43991 | BioStudies |

REPOSITORIES: biostudies

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