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Genome wide binding and transcriptome analysis of human FXR in primary human hepatocytes [HTS]


ABSTRACT: We report the genome-wide profiling of FXR binding by ChIP-seq from GW4064 or DMSO treated primary human hepatocytes. We reported altered RNA expression profiles in primary human hepatocypes upon GW4064 treatment compared to DMSO control by RNA-seq. We also reported the altered RNA expression profiles in livers from WT C57BL/6J mice upon GW4064 treatment compared to vehicle control. Primary human hepatocytes were treated with 5uM GW4064 or DMSO control, 1 hour later, cells were fixed and collected for chromatin isolation. 24 hours post treatment, cells were isolated for RNA isolation. This submission represents HTS component of study.

SUBMITTER: Le Zhan 

PROVIDER: E-GEOD-57227 | BioStudies | 2014-07-24

SECONDARY ACCESSION(S): SRP041597

REPOSITORIES: biostudies

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