Dataset Information


Specificity, propagation and memory of pericentric heterochromatin in mouse fibroblasts

ABSTRACT: We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase Suv39h1/2 demarcate the PCH state. From the experimental data we developed a predictive mathematical model that explains how chromatin-bound Suv39h1/2 complexes act as nucleation sites and propagate a spatially confined PCH domain with elevated histone H3 trimethylation levels via chromatin dynamics. Enrichment of HP1, Suv39h1/h2, H3K9me3 and H3K36me3 was assessed by ChIP-seq in NPCs derived from ESCs showing differential occupation at intergenic major satellite repeats and enrichment of heterochromatin factors. ChIP-seq of HP1, Suv39h1, Suv39h2, H3K9me3, H3K36me3 in NPCs

ORGANISM(S): Mus musculus

PROVIDER: E-GEOD-58555 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

2014-08-12 | E-GEOD-58555 | ArrayExpress
| GSE58555 | GEO
| S-EPMC5330444 | BioStudies
| S-EPMC7469483 | BioStudies
| S-EPMC4960310 | BioStudies
2014-01-01 | S-EPMC4078803 | BioStudies
| S-EPMC8303541 | BioStudies
| S-EPMC4299515 | BioStudies
| S-EPMC7898489 | BioStudies
| S-EPMC8609021 | BioStudies