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The activity and subcellular distribution of the peroxisomal enzyme acyl-CoA oxidase in human blood platelets.


ABSTRACT: The peroxisomal enzyme acyl-CoA oxidase is localized in the 'dense-tubular-system-enriched fraction', probably identical with the endoplasmic reticulum, in human blood platelets. This localization is strongly different from the localization of catalase which seems to be a cytosolic enzyme, in agreement with Marcus, Zucker-Franklin, Safir & Ullman [(1966) J. Clin. Invest. 45, 14-28]. A localization of acyl-CoA oxidase in the endoplasmic reticulum seems to be in good accordance with the important role of peroxisomes in the metabolism of prostaglandins, as recently demonstrated by Diczfalusy, Kase, Alexson & Bjørkhem [(1991) J. Clin. Invest. 88, 978-984].

SUBMITTER: Farstad M 

PROVIDER: S-EPMC1132979 | BioStudies | 1992-01-01

SECONDARY ACCESSION(S): 10.1042/bj2860829

REPOSITORIES: biostudies

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