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Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate.


ABSTRACT: The maximum rates of lactate oxidation and lipogenesis from lactate by early-neonatal brain slices were considerably greater than those for utilization of glucose and 3-hydroxybutyrate at physiological concentrations. Lactate inhibited glucose utilization, but enhanced 3-hydroxybutyrate utilization. 3-Hydroxybutyrate inhibited lactate and glucose utilization. Glucose slightly inhibited oxidation of lactate and 3-hydroxybutyrate, but scarcely enhanced lipogenesis from these substrates.

PROVIDER: S-EPMC1146593 | BioStudies | 1986-01-01

REPOSITORIES: biostudies

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