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Involvement of calcium ions in the activation of ornithine decarboxylase by isoprenaline evaluated 'in situ' in the perfused rat heart.


ABSTRACT: Ornithine decarboxylase activity evaluated during the perfusion of isolated rat hearts by a method 'in situ' was rapidly increased when the hearts were infused with isoprenaline (isoproterenol). Omission of Ca2+ from the perfusion medium or the administration of verapamil to the perfused hearts decreased the isoprenaline-stimulated ornithine decarboxylase activity, whereas a marked stimulatory effect was registered when the hearts were perfused with the Ca2+ ionophore A23187.

SUBMITTER: Guarnieri C 

PROVIDER: S-EPMC1152035 | BioStudies | 1983-01-01

SECONDARY ACCESSION(S): 10.1042/bj2120241

REPOSITORIES: biostudies

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