Unknown

Dataset Information

0

Stimulatory effect of the intestinal peptide PHI on glycogenolysis and gluconeogenesis in isolated rat hepatocytes.


ABSTRACT: The newly isolated peptide PHI provoked a dose-dependent stimulation of glycogenolysis and gluconeogenesis in isolated rat hepatocytes; at 1 microM-PHI, both processes were increased 1.6-fold as compared with basal values. These PHI-mediated effects were accompanied by the activation of glycogen phosphorylase and the inactivation of pyruvate kinase. PHI (1 microM) also caused a 2-fold increase in hepatocyte cyclic AMP.

SUBMITTER: Feliu JE 

PROVIDER: S-EPMC1152344 | BioStudies | 1983-01-01

SECONDARY ACCESSION(S): 10.1042/bj2140999

REPOSITORIES: biostudies

Similar Datasets

1983-01-01 | S-EPMC1152293 | BioStudies
1999-01-01 | S-EPMC1220495 | BioStudies
1988-01-01 | S-EPMC1135466 | BioStudies
1987-01-01 | S-EPMC1148479 | BioStudies
1991-01-01 | S-EPMC1151282 | BioStudies
2017-01-01 | S-EPMC5492176 | BioStudies
1990-01-01 | S-EPMC1131116 | BioStudies
1984-01-01 | S-EPMC1153645 | BioStudies
1986-01-01 | S-EPMC1147056 | BioStudies
2019-01-01 | S-EPMC6834909 | BioStudies