Unknown

Dataset Information

0

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase.


ABSTRACT: Liver of rat foetuses from 14 to 19 days of gestation and cultured hepatocytes derived from foetuses of 14 or 15 days gestation show a limited capacity to transaminate tyrosine. This low tyrosine transamination activity can be ascribed to aspartate aminotransferase. Definitive tyrosine aminotransferase can be demonstrated in 1-day-old cultures of hepatocytes taken from 19-day foetuses, but not from 15-day foetuses. However, after 3 days of culture hepatocytes from 15-day foetuses are able to synthesize tyrosine aminotransferase. Induction studies reveal that dexamethasone is capable of increasing tyrosine aminotransferase activity once it is detectable in culture.

SUBMITTER: Yeoh GC 

PROVIDER: S-EPMC1161030 | BioStudies | 1979-01-01

SECONDARY ACCESSION(S): 10.1042/bj1800153

REPOSITORIES: biostudies

Similar Datasets

1981-01-01 | S-EPMC1163248 | BioStudies
1980-01-01 | S-EPMC1161615 | BioStudies
1969-01-01 | S-EPMC1185063 | BioStudies
1980-01-01 | S-EPMC1161980 | BioStudies
1980-01-01 | S-EPMC1162147 | BioStudies
1974-01-01 | S-EPMC1168488 | BioStudies
1977-01-01 | S-EPMC1183798 | BioStudies
1985-01-01 | S-EPMC1144885 | BioStudies
2019-01-01 | S-EPMC7102661 | BioStudies
1984-01-01 | S-EPMC1153630 | BioStudies