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Huntington's-chorea fibroblasts. Cellular protein glycosylation.


ABSTRACT: Five cell cultures of Huntington's-chorea fibroblasts exhibit greater than normal protein and lipid glycosylation when labelled with [U-14C]glucosamine. Oligosaccharide--polypeptide chains from all molecular-weight ranges are labelled differentially on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. This difference in protein glycosylation is not accompanied by any apparent difference in general cellular protein synthesis or by a differential rate of glucosamine uptake or decreased degradation of [14C]glycosylated macromolecules. Additionally [U-14C]glucosamine exclusively labels hexosamines and sialic acid of cellular macromolecules.

SUBMITTER: Hung WY 

PROVIDER: S-EPMC1162151 | BioStudies | 1980-01-01

REPOSITORIES: biostudies

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