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The metabolism of phenolic acids in the rat.


ABSTRACT: Some of the enzyme systems in the formation of p-hydroxybenzoate from tyrosine have been studied in the rat liver in vitro. The conversion of p-hydroxycinnamate into p-hydroxybenzoate, which was found in rat liver mitochondria showed a number of differences when compared with the beta-oxidation of fatty acids. Studies with p-hydroxy[U-(14)C]cinnamate indicated that (14)CO(2) was released during the formation of p-hydroxybenzoate. The formation of p-hydroxycinnamate from tyrosine of p-hydroxyphenyl-lactate could not be demonstrated in vitro. The interconversion of p-hydroxycinnamate and p-hydroxyphenylpropionate was demonstrated in rat liver mitochondria.

PROVIDER: S-EPMC1168030 | BioStudies | 1974-01-01

REPOSITORIES: biostudies

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