Unknown

Dataset Information

0

A direct pathway for the metabolism of propionate in cell extracts from Moraxella lwoffi.


ABSTRACT: 1. Extracts from Moraxella lwoffi oxidize propionate, but at a low rate when compared with whole cells. 2. This oxidative activity requires the formation of propionyl-CoA. 3. Enzymes catalysing the formation of propionyl phosphate and propionyl-CoA are present. The presence of a propionyl-CoA hydrolase is considered to be an artifact, but partly responsible for the low rates of oxidation. 4. Enzymes catalysing the reduction of NAD(+) and the formation of pyruvate with propionyl-CoA as substrate are also present. 5. That the only pathway for the metabolism of propionate in extracts is a direct one to acetate via pyruvate was confirmed by the use of (14)C-labelled materials. 6. A possible sequence of enzyme-catalysed reactions that will account for the experimental observations is described.

SUBMITTER: Hodgson B 

PROVIDER: S-EPMC1198605 | BioStudies | 1968-01-01

SECONDARY ACCESSION(S): 10.1042/bj1070019

REPOSITORIES: biostudies

Similar Datasets

1988-01-01 | S-EPMC1148929 | BioStudies
1968-01-01 | S-EPMC1198604 | BioStudies
1969-01-01 | S-EPMC1187496 | BioStudies
1995-01-01 | S-EPMC1136229 | BioStudies
1965-01-01 | S-EPMC1214340 | BioStudies
1965-01-01 | S-EPMC1214338 | BioStudies
1967-01-01 | S-EPMC1270631 | BioStudies
2020-01-01 | S-EPMC7324963 | BioStudies
1988-01-01 | S-EPMC1135119 | BioStudies
1000-01-01 | S-EPMC3593168 | BioStudies