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Mapping of the binding site for Mannheimia haemolytica leukotoxin within bovine CD18.


ABSTRACT: To map the site involved in Mannheimia haemolytica leukotoxin (LktA) binding and biological activity within bovine CD18, bovine x human CD18 chimeric constructs were generated and coexpressed with bovine CD11a in K562 cells. Studies with the chimeric leukocyte function-associated antigen 1 transductants demonstrate that the site required for LktA binding and biological effects resides within amino acid residues 500 and 600 of the extracellular region of bovine CD18.

SUBMITTER: Dileepan T 

PROVIDER: S-EPMC1201247 | BioStudies | 2005-01-01

REPOSITORIES: biostudies

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