Unknown

Dataset Information

0

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.


ABSTRACT: In a model of staurosporine-induced apoptosis using EAhy926 endothelial cells, inhibition of apoptosis by activated protein C was dose-dependent and required the enzyme's active site, implicating activated protein C-mediated proteolysis. Consistent with this implication, both protease-activated receptor-1 (PAR-1) and endothelial cell protein C receptor (EPCR) were required for the anti-apoptotic effects of activated protein C.

PROVIDER: S-EPMC1223481 | BioStudies | 2003-01-01

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC6356956 | BioStudies
| S-EPMC4155268 | BioStudies
| S-EPMC2738580 | BioStudies
1992-01-01 | S-EPMC1132828 | BioStudies
| S-EPMC3870021 | BioStudies
| S-EPMC6494677 | BioStudies
| S-EPMC4661071 | BioStudies
| S-EPMC5527318 | BioStudies
| S-EPMC3731934 | BioStudies
| S-EPMC6737157 | BioStudies