Dataset Information


Cytochrome c-d regulates developmental apoptosis in the Drosophila retina.

ABSTRACT: The role of cytochrome c (Cyt c) in caspase activation has largely been established from mammalian cell-culture studies, but much remains to be learned about its physiological relevance in situ. The role of Cyt c in invertebrates has been subject to considerable controversy. The Drosophila genome contains distinct cyt c genes: cyt c-p and cyt c-d. Loss of cyt c-p function causes embryonic lethality owing to a requirement of the gene for mitochondrial respiration. By contrast, cyt c-d mutants are viable but male sterile. Here, we show that cyt c-d regulates developmental apoptosis in the pupal eye. cyt c-d mutant retinas show a profound delay in the apoptosis of superfluous interommatidial cells and perimeter ommatidial cells. Furthermore, there is no apoptosis in mutant retinal tissues for the Drosophila homologues of apoptotic protease-activating factor 1 (Ark) and caspase 9 (Dronc). In addition, we found that cyt c-d--as with ark and dronc-regulates scutellar bristle number, which is known to depend on caspase activity. Collectively, our results indicate a role of Cyt c in caspase regulation of Drosophila somatic cells.

PROVIDER: S-EPMC1559679 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC1356363 | BioStudies
| S-EPMC300883 | BioStudies
| S-EPMC3083146 | BioStudies
| S-EPMC2944066 | BioStudies
| S-EPMC16328 | BioStudies
2006-01-01 | S-EPMC1592896 | BioStudies
| S-EPMC3839108 | BioStudies
| S-EPMC4318144 | BioStudies
| S-EPMC3164697 | BioStudies
| S-EPMC5313150 | BioStudies