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Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.


ABSTRACT: Spontaneous quinolone-resistant mutants obtained from Salmonella typhimurium Su694 were screened for mutations by direct DNA sequencing of an amplified PCR gyrA fragment. Substitutions Ser-83-->Phe (Ser83Phe), Ser83Tyr, Asp87Tyr, and Asp87Asn and double mutation Ala67Pro-Gly81Ser, which resulted in decreased sensitivities to ciprofloxacin, enoxacin, pefloxacin, norfloxacin, ofloxacin, and nalidixic acid, were found. The levels of resistance to quinolones for each mutant were determined.

SUBMITTER: Reyna F 

PROVIDER: S-EPMC162795 | BioStudies | 1995-01-01T00:00:00Z

SECONDARY ACCESSION(S): U21957

REPOSITORIES: biostudies

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