Dataset Information


Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity.

ABSTRACT: The roles of interleukin-4 (IL-4) and IL-13 in the regulation of immunity to Leishmania donovani infection are still poorly understood. Here we show that the increased parasite load observed in IL-4(-/-) and IL-4 receptor alpha(-/-) mice correlates with retarded granuloma maturation and antileishmanial activity and that the increased parasite load observed in IL-4 receptor alpha(-/-) mice correlates with increased NOS2 expression and decreased serum gamma interferon levels. IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas.


PROVIDER: S-EPMC166035 | BioStudies | 2003-01-01

SECONDARY ACCESSION(S): 10.1128/IAI.71.8.4804-4807.2003

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7038143 | BioStudies
2015-01-01 | S-EPMC4730870 | BioStudies
2012-01-01 | S-EPMC4056845 | BioStudies
2013-01-01 | S-EPMC3674182 | BioStudies
1000-01-01 | S-EPMC4176393 | BioStudies
1000-01-01 | S-EPMC4068582 | BioStudies
2020-01-01 | S-EPMC7502791 | BioStudies
2019-01-01 | S-EPMC6529017 | BioStudies
2020-01-01 | S-EPMC7491717 | BioStudies
2016-01-01 | S-EPMC4841789 | BioStudies