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Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.


ABSTRACT: The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and gene disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinone.

SUBMITTER: Otten SL 

PROVIDER: S-EPMC177529 | BioStudies | 1995-01-01T00:00:00Z

SECONDARY ACCESSION(S): L28170

REPOSITORIES: biostudies

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