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Loss of fibulin-2 expression is associated with breast cancer progression.


ABSTRACT: Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.

SUBMITTER: Yi CH 

PROVIDER: S-EPMC1854949 | BioStudies | 2007-01-01T00:00:00Z

REPOSITORIES: biostudies

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