Unknown

Dataset Information

0

Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand.


ABSTRACT: Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

SUBMITTER: Poly F 

PROVIDER: S-EPMC1932940 | BioStudies | 2007-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5557513 | BioStudies
2006-01-01 | S-EPMC1424674 | BioStudies
2005-01-01 | S-EPMC1153751 | BioStudies
2015-01-01 | S-EPMC4499754 | BioStudies
2014-01-01 | S-EPMC3917866 | BioStudies
2017-01-01 | S-EPMC5403884 | BioStudies
2014-01-01 | S-EPMC4294202 | BioStudies
2004-01-01 | S-EPMC321600 | BioStudies
2017-01-01 | S-EPMC5530802 | BioStudies
1000-01-01 | S-EPMC2643618 | BioStudies