Unknown

Dataset Information

0

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.


ABSTRACT: We have characterized a distinct, late transitional B cell subset, CD21(int) transitional 2 (T2) B cells. In contrast to early transitional B cells, CD21(int) T2 B cells exhibit augmented responses to a range of potential microenvironmental stimuli. Adoptive transfer studies demonstrate that this subset is an immediate precursor of both follicular mature and marginal zone (MZ) B cells. In vivo, a large percentage of CD21(int) T2 B cells has entered the cell cycle, and the cycling subpopulation exhibits further augmentation in mitogenic responses and B cell-activating factor of the TNF family (BAFF) receptor expression. Consistent with these features, CD21(int) T2 cells exhibit preferential responses to BAFF-facilitated homeostatic signals in vivo. In addition, we demonstrate that M167 B cell receptor (BCR) idiotypic-specific B cells are first selected within the cycling CD21(int) T2 population, ultimately leading to preferential enrichment of these cells within the MZ B cell compartment. These data, in association with the coordinate role for BAFF and microenvironmental cues in determining the mature BCR repertoire, imply that this subset functions as a unique selection point in peripheral B cell development.

SUBMITTER: Meyer-Bahlburg A 

PROVIDER: S-EPMC2234381 | BioStudies | 2008-01-01

REPOSITORIES: biostudies

Similar Datasets

2010-01-01 | S-EPMC3040573 | BioStudies
2018-01-01 | S-EPMC6779322 | BioStudies
2010-01-01 | S-EPMC2950883 | BioStudies
2014-01-01 | S-EPMC4046845 | BioStudies
2015-01-01 | S-EPMC4324157 | BioStudies
2005-01-01 | S-EPMC1895038 | BioStudies
2016-01-01 | S-EPMC4868625 | BioStudies
2014-01-01 | S-EPMC4028688 | BioStudies
2011-01-01 | S-EPMC3155302 | BioStudies
2015-01-01 | S-EPMC4444153 | BioStudies