Dataset Information


Detection of GD2-positive cells in bone marrow samples and survival of patients with localised neuroblastoma.

ABSTRACT: The impact of bone marrow (BM) GD2-positive cells on survival has been evaluated in 145 Italian children with localised neuroblastoma (NB) evaluated at diagnosis by anti-GD2 immunocytochemistry. Nineteen of these (13.1%) were found to be BM GD2-positive, with the number of positive cells ranging between 1 and 155 out of 1 x 10(6) total cells analysed. Seven/19 (38.8%) GD2-positive vs 12/126 (9.5%) GD2-negative patients relapsed. The 5-year event-free survival (EFS) and overall survival of the GD2-positive patients was significantly worse than that of the GD2-negative ones (62.2 vs 89.9%, P<0.001; and 74.9 vs 95.9%, P=0.005, respectively). GD2 positivity was not associated to other known risk factors, and in particular to Myc-N amplification and 1p deletion. Among Myc-N-negative patients, the EFS of those negative for both GD2 and 1p deletion was significantly better than in children positive for either one of these two markers (EFS=96.9 vs 66.0%, P<0.001). In conclusion, GD2 positivity may represent a prognostic marker for patients with non-metastatic NB without Myc-N amplification, and its combination with genetic alterations might help identifying patients that require a more careful follow-up.


PROVIDER: S-EPMC2361437 | BioStudies | 2008-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7723438 | BioStudies
2012-01-01 | S-EPMC3253802 | BioStudies
2018-03-29 | GSE112447 | GEO
2017-05-31 | GSE90689 | GEO
2012-01-01 | S-EPMC3507146 | BioStudies
2019-01-01 | S-EPMC6306059 | BioStudies
2018-01-01 | S-EPMC5773840 | BioStudies
1000-01-01 | S-EPMC5739560 | BioStudies
2015-01-01 | S-EPMC4314455 | BioStudies
2019-01-01 | S-EPMC6571039 | BioStudies