Unknown

Dataset Information

0

Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis.


ABSTRACT: The Drosophila let-7-Complex (let-7-C) is a polycistronic locus encoding three ancient microRNAs: let-7, miR-100, and fly lin-4 (miR-125). We find that the let-7-C locus is principally expressed in the pupal and adult neuromusculature. let-7-C knockout flies appear normal externally but display defects in adult behaviors (e.g., flight, motility, and fertility) as well as clear juvenile features in their neuromusculature. We find that the function of let-7-C to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition is carried out predominantly by let-7 alone. This heterochronic role of let-7 is likely just one of the ways in which let-7-C promotes adult behavior.

SUBMITTER: Sokol NS 

PROVIDER: S-EPMC2428057 | BioStudies | 2008-01-01

REPOSITORIES: biostudies

Similar Datasets

2005-01-01 | S-EPMC2596717 | BioStudies
2005-01-01 | S-EPMC3969732 | BioStudies
2014-01-01 | S-EPMC3916362 | BioStudies
2008-01-01 | S-EPMC2736146 | BioStudies
2012-01-01 | S-EPMC3401410 | BioStudies
2011-01-01 | S-EPMC3160099 | BioStudies
2005-01-01 | S-EPMC2572564 | BioStudies
2007-01-01 | S-EPMC1965540 | BioStudies
2019-01-01 | S-EPMC6631683 | BioStudies
1000-01-01 | S-EPMC4217435 | BioStudies