Dataset Information


Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.

ABSTRACT: The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. We performed a dense whole genome linkage scan using 3878 unlinked SNPs in a large pedigree derived from a population isolate sample of 328 Plains American Indians. Alpha (8-13 Hz), theta (4-8 Hz) and beta (13-30 Hz) EEG power was heritable (0.58-0.27) and stable over a 2 year period (r = 0.82-0.53). Genetic correlations between frequency bands were high (0.75). Linkage peaks for EEG power in all three frequency bands converged on chromosome 5q13-14 with genome-wide significant LOD scores of 3.5 (empirical p<0.0001) for alpha and beta power. A logical candidate gene, corticotropin releasing hormone-binding protein (CRH-BP), was located at the apex of these convergent linkage peaks. CRH-BP was significantly associated with alpha power in the Plains Indians and also in a replication sample of 188 Caucasians. Moreover, the same SNPs and haplotypes, located within the CRH-BP haplotype block, were also associated with anxiety disorders in the Plains Indians and alcohol use disorders in the Caucasians. CRH-BP modulates CRH which influences cortical and hippocampal EEG activity and is the primary mediator of the neuroendocrine stress response. Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction.


PROVIDER: S-EPMC2575401 | BioStudies | 2008-01-01

REPOSITORIES: biostudies

Similar Datasets

2006-01-01 | S-EPMC4516162 | BioStudies
2006-01-01 | S-EPMC2748409 | BioStudies
2010-01-01 | S-EPMC2889314 | BioStudies
2011-01-01 | S-EPMC3139721 | BioStudies
2009-01-01 | S-EPMC2754808 | BioStudies
2009-01-01 | S-EPMC2656604 | BioStudies
2018-01-01 | S-EPMC5995627 | BioStudies
2018-01-01 | S-EPMC6014641 | BioStudies
2017-01-01 | S-EPMC5786859 | BioStudies
2009-01-01 | S-EPMC2660384 | BioStudies