Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Griffero F
PROVIDER: S-EPMC262550 | BioStudies | 2003-01-01
SECONDARY ACCESSION(S): 10.1128/JVI.77.23.12552-12561.2003
REPOSITORIES: biostudies
Diaz-Griffero Felipe F Hoschander Steven A SA Brojatsch Jürgen J
Journal of virology 20031201 23
Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been extensively studied, but the molecular basis of this process has not been established. Here we show that superinfection, which has been linked to cell killing by ALV-B, plays no crucial role in cell death induction. Instead, we show that signaling by the ALV-B receptor, TVB(S3), a member of the tumor necrosis factor receptor family, is essential for ALV-B-mediated cell death. TVB(S3) activated caspase-dependent apoptosi ...[more]