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Functionalized analogues of an unnatural amino acid that mimics a tripeptide beta-strand.


ABSTRACT: This paper introduces polar and hydrophobic variants of the unnatural amino acid Hao, which mimics the hydrogen-bonding functionality of one edge of a beta-strand. In these variants, the methyl side chain of Hao is replaced with acidic, basic, and hydrophobic groups. These modifications can impart improved solubility and additional side-chain interactions to peptides containing Hao.

PROVIDER: S-EPMC2659333 | BioStudies | 2008-01-01T00:00:00Z

REPOSITORIES: biostudies

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