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Lack of complex I is associated with oncocytic thyroid tumours.


ABSTRACT: Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.

PROVIDER: S-EPMC2694433 | BioStudies |

REPOSITORIES: biostudies

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