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An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.

ABSTRACT: An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

PROVIDER: S-EPMC2702766 | BioStudies |

REPOSITORIES: biostudies

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