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Copper-mediated amidation of heterocyclic and aromatic C-H bonds.


ABSTRACT: A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC2776381 | BioStudies | 2009-01-01T00:00:00Z

REPOSITORIES: biostudies

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