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Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.


ABSTRACT: The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.

SUBMITTER: Lim KH 

PROVIDER: S-EPMC2798468 | BioStudies | 2010-01-01T00:00:00Z

REPOSITORIES: biostudies

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