Unknown

Dataset Information

0

Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.


ABSTRACT: Activation of certain classes of G protein-coupled receptors (GPCRs) can lead to alterations in the actin cytoskeleton, gene transcription, cell transformation, and other processes that are known to be regulated by Rho family small-molecular-weight GTPases. Although these responses can occur indirectly via cross-talk from canonical heterotrimeric G protein cascades, it has recently been demonstrated that Dbl family Rho guanine nucleotide exchange factors (RhoGEFs) can serve as the direct downstream effectors of heterotrimeric G proteins. Heterotrimeric Galpha(12/13), Galpha(q), and Gbetagamma subunits are each now known to directly bind and regulate RhoGEFs. Atomic structures have recently been determined for several of these RhoGEFs and their G protein complexes, providing fresh insight into the molecular mechanisms of signal transduction between GPCRs and small molecular weight G proteins. This review covers what is currently known about the structure, function, and regulation of these recently recognized effectors of heterotrimeric G proteins.

SUBMITTER: Aittaleb M 

PROVIDER: S-EPMC2812070 | BioStudies | 2010-01-01

REPOSITORIES: biostudies

Similar Datasets

2005-01-01 | S-EPMC2794341 | BioStudies
1000-01-01 | S-EPMC1142213 | BioStudies
2008-01-01 | S-EPMC2634461 | BioStudies
1000-01-01 | S-EPMC2784731 | BioStudies
2007-01-01 | S-EPMC2655113 | BioStudies
2008-01-01 | S-EPMC2174166 | BioStudies
2006-01-01 | S-EPMC1637559 | BioStudies
1000-01-01 | S-EPMC4875565 | BioStudies
2007-01-01 | S-EPMC1876549 | BioStudies
1000-01-01 | S-EPMC2555931 | BioStudies