Dataset Information


IL-17RC: a partner in IL-17 signaling and beyond.

ABSTRACT: The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure-function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health.

PROVIDER: S-EPMC2837117 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC2897912 | BioStudies
| S-EPMC2849293 | BioStudies
| S-EPMC4419340 | BioStudies
| S-EPMC4952011 | BioStudies
| S-EPMC2973994 | BioStudies
| S-EPMC8268646 | BioStudies
| S-EPMC7267874 | BioStudies
| S-EPMC5566378 | BioStudies
| S-EPMC5149406 | BioStudies
| S-EPMC8566063 | BioStudies