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IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana.


ABSTRACT: DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA-binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway.

SUBMITTER: Ausin I 

PROVIDER: S-EPMC2842998 | BioStudies | 2009-01-01

REPOSITORIES: biostudies

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