Unknown

Dataset Information

0

Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep.


ABSTRACT: Brain activity in sleep plays a crucial role in memory consolidation, an offline process that determines the long-term strength of memory traces. Consolidation efficacy differs across individuals, but the brain activity dynamics underlying these differences remain unknown. Here, we studied how interindividual variability in fear memory consolidation relates to neural activity in brain structures that participate in Pavlovian fear learning. From the end of training to testing 24 h later, some rats showed increased and others decreased conditioned fear responses. We found that overnight bidirectional changes in fear memory were selectively correlated with modifications in theta coherence between the amygdala, medial prefrontal cortex, and hippocampus during paradoxical sleep. Thus, our results suggest that theta coordination in the limbic system may influence interindividual differences in memory consolidation of aversive experiences.

SUBMITTER: Popa D 

PROVIDER: S-EPMC2851973 | BioStudies | 2010-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5384212 | BioStudies
2018-01-01 | S-EPMC7556718 | BioStudies
2009-01-01 | S-EPMC2665156 | BioStudies
2021-01-01 | S-EPMC7900186 | BioStudies
1000-01-01 | S-EPMC6132282 | BioStudies
1000-01-01 | S-EPMC4434562 | BioStudies
1000-01-01 | S-EPMC4233998 | BioStudies
2008-01-01 | S-EPMC2597638 | BioStudies
2007-01-01 | S-EPMC3055246 | BioStudies
2014-01-01 | S-EPMC3950278 | BioStudies