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Utahmycins a and B, azaquinones produced by an environmental DNA clone.


ABSTRACT: Two new azaquinones, utahmycins A (1) and B (2), were isolated from cultures of Streptomyces albus J1704 transformed with the environmental DNA-derived Erd gene cluster. The structures of 1 and 2 were elucidated by spectroscopic analyses. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both metabolites appear to arise from the addition of a nitrogen atom to erdacin biosynthetic intermediates. Utahmycin A (1) is the first example of a biologically derived 1,3-dimethyl-2-azaanthraquinone.

SUBMITTER: Bauer JD 

PROVIDER: S-EPMC2893554 | BioStudies | 2010-01-01

REPOSITORIES: biostudies

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