2-Amino-5,7-bis-(4-fluoro-phen-yl)-1',3'-dimethyl-7,8-dihydro-spiro-[pyrido[2,3-d]pyrimidine-6(5H),5'-pyrimidine]-2',4,4',6'(3H,1'H,3'H,5'H)-tetra-one ethanol solvate.
ABSTRACT: In the mol-ecule of the title compound, C(24)H(20)F(2)N(6)O(4)·C(2)H(5)OH, the pyrimidine ring is oriented at dihedral angles of 42.64?(3) and 62.94?(3)° with respect to the benzene rings, while the dihedral angle between the benzene rings is 74.45?(3)°. The pyridine ring adopts an envelope conformation. In the crystal structure, inter-molecular N-H?O and O-H?N hydrogen bonds link the mol-ecules into a two-dimensional network, forming R(2) (2)(8) ring motifs. ?-? contacts between the pyrimidine and benzene rings [centroid-centroid distances = 3.516?(1) and 3.927?(1)?Å] may further stabilize the structure.
PROVIDER: S-EPMC2969385 | BioStudies |