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(2Z)-2-Fluoro-N-{4-[5-(4-fluoro-phen-yl)-2-methyl-sulfanyl-1H-imidazol-4-yl]-2-pyrid-yl}-3-phenyl-acrylamide.


ABSTRACT: The asymmetric unit of the title compound, C(24)H(18)F(2)N(4)OS, contains two crystallographically independent mol-ecules, A and B, which are linked into two chains of A and B mol-ecules by inter-molecular N-H⋯O hydrogen bonds. The three-dimensional network is stabilized by π-π inter-actions between the pyridine rings and phenyl rings of different residues, with centroid-centroid distances of 3.793 (1) and 3.666 (2) Å. The mol-ecular conformation is stabilized by intra-molecular N-H⋯F hydrogen bonds (2.15/2.15Å). The imidazole rings make dihedral angles of 39.5 (2)/38.5 (2) and 31.8 (2)/33.2 (2)° with the 4-fluoro-phenyl rings and the pyridine rings, respectively. The methyl group of molecule A is disorderd in a 0.60:0.40 ratio.

PROVIDER: S-EPMC2971986 | BioStudies |

REPOSITORIES: biostudies

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