Dataset Information


Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis.

ABSTRACT: BACKGROUND: Observational studies and randomized controlled trials have yielded inconsistent findings about the association between the use of acid-suppressive drugs and the risk of pneumonia. We performed a systematic review and meta-analysis to summarize this association. METHODS: We searched three electronic databases (MEDLINE [PubMed], Embase and the Cochrane Library) from inception to Aug. 28, 2009. Two evaluators independently extracted data. Because of heterogeneity, we used random-effects meta-analysis to obtain pooled estimates of effect. RESULTS: We identified 31 studies: five case-control studies, three cohort studies and 23 randomized controlled trials. A meta-analysis of the eight observational studies showed that the overall risk of pneumonia was higher among people using proton pump inhibitors (adjusted odds ratio [OR] 1.27, 95% confidence interval [CI] 1.11-1.46, I(2) 90.5%) and histamine(2) receptor antagonists (adjusted OR 1.22, 95% CI 1.09-1.36, I(2) 0.0%). In the randomized controlled trials, use of histamine(2) receptor antagonists was associated with an elevated risk of hospital-acquired pneumonia (relative risk 1.22, 95% CI 1.01-1.48, I(2) 30.6%). INTERPRETATION: Use of a proton pump inhibitor or histamine(2) receptor antagonist may be associated with an increased risk of both community- and hospital-acquired pneumonia. Given these potential adverse effects, clinicians should use caution in prescribing acid-suppressive drugs for patients at risk.


PROVIDER: S-EPMC3042441 | BioStudies | 2011-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC5770505 | BioStudies
2011-01-01 | S-EPMC3101476 | BioStudies
2015-01-01 | S-EPMC4493004 | BioStudies
2017-01-01 | S-EPMC5234823 | BioStudies
2014-01-01 | S-EPMC4199831 | BioStudies
2016-01-01 | S-EPMC4951104 | BioStudies
2019-01-01 | S-EPMC6505944 | BioStudies
1000-01-01 | S-EPMC3824882 | BioStudies
2020-01-01 | S-EPMC7190057 | BioStudies
2017-01-01 | S-EPMC5218810 | BioStudies