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1-(Piperidin-1-yl)-3-(2,4,6-trimethyl-phen-yl)propan-2-ol.

ABSTRACT: The title compound, C(17)H(27)NO, features a bufferfly-shaped substituted 2-propanol having an aromatic ring on the 1-carbon and a piperidine ring on the 3-carbon. The piperidine ring adopts a chair conformation and its N atom shows a trigonal coordination. In the crystal, the hy-droxy group inter-acts with the N atom of an inversion-related mol-ecule, generating an O-H?N hydrogen-bonded dimer.

PROVIDER: S-EPMC3052162 | BioStudies | 2011-01-01T00:00:00Z

REPOSITORIES: biostudies

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4-(4-Chloro-phen-yl)piperidin-4-ol.

Project description:In the title compound, C(11)H(14)ClNO, the piperidine ring adopts a chair conformation: the hydroxyl substituent and the N-bound H atom occupy the axial positions, while the benzene ring occupies the equatorial position. In the crystal, the mol-ecules are linked into a centrosymmetric tetra-mer through strong O-H?N and weak N-H?O hydrogen bonds; the N and O atoms act as both donor and acceptor for these inter-actions. The tetra-mers are further joined by hydrogen bonds into a layer parallel to (100).

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Project description:In the title compound, C29H32N2O2, the piperidine ring exists in a chair conformation (the bond-angle sum at the sp (2)-hybridized C atom is 359.79°). The phenyl rings and the methyl group substituted on the heterocyclic ring are in equatorial orientations. In the crystal, pairs of C-H?? inter-actions result in the formation of inversion dimers.

2013-01-01 | S-EPMC3793771 | BioStudies

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Project description:In the title compound, C(15)H(15)NO, the dihedral angle between the benzene rings is 2.25?(2)°. The C-C-C-O atoms of the propanol side chain are in a gauche conformation [torsion angle = -60.5?(2)°]. In the crystal, O-H?O hydrogen bonds link the mol-ecules into C(2) chains propagating in [100]. The O-bonded H atom is disordered over two sites of equal occupancy.

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Project description:In the title compound, C(23)H(25)NO, an intra-molecular O-H?N hydrogen bond defines the mol-ecular conformation; the naphthol mean plane and the benzene ring form a dihedral angle of 75.8?(2)°. The piperidine ring adopts a chair conformation. The crystal packing exhibits no short inter-molecular contacts.

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Crystal structure of the adduct (4-chloro-phen-yl)(4-hy-droxy-piperidin-1-yl)methanone-(4-chloro-phen-yl)(piperidin-1-yl)methanone (0.75/0.25).

Project description:In the title compound, 0.75C12H14ClNO2·0.25C12H14ClNO, which is an adduct comprising 0.75 4-hy-droxy-piperidin-1-yl or 0.25 4-piperidin-1-yl substituents on a common (4-chloro-phen-yl)methanone component; the dihedral angles between the benzene ring and the two piperidine rings are 51.6?(3) and 89.5?(7)°, respectively. The hy-droxy-piperidine ring is in a bis-ectional oriention (bi) with the phenyl ring. In the crystal, inter-molecular O-H?O hydrogen bonds between the hy-droxy-piperidine group and the keto O atom lead to the formation of chains extending along the c- axis direction.

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3-(Piperidin-1-yl)-6-(1H-pyrazol-1-yl)pyridazine.

Project description:In the title compound, C(12)H(15)N(5), the piperidine ring adopts a chair conformation with the substituent C atom in an equatorial site and the dihedral angle between the pyridazine and pyrazole ring planes is 10.36?(2)°.

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4-{[4-(Hy-droxy-meth-yl)piperidin-1-yl]meth-yl}phenol.

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1-Methyl-amino-3-(2,4,6-trimethyl-phen-yl)propan-2-ol.

Project description:The methyl-amino-propyl chain in the title compound, C(13)H(21)NO, adopts an extended zigzag conformation and the N atom shows a trigonal coordination. The N atom acts as hydrogen-bond acceptor to the hy-droxy group of an adjacent mol-ecule, generating a helical chain running along the b axis. The amino H atom is not involved in hydrogen bonding.

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1-[(Z)-2-Phenyl-hydrazin-1-yl-idene]-1-(piperidin-1-yl)propan-2-one.

Project description:A Z configuration about the imine bond [1.3025?(18)?Å] in the title compound, C(14)H(19)N(3)O, allows for the formation of an intra-moleclar N-H?N hydrogen bond between the hydrazone H and piperidine N atoms; the carbonyl group is disposed to lie over the piperidine residue, which is in a chair form. A twist between the terminal benzene ring and the hydrazine residue is seen [N-N-C-C torsion angle = 163.81?(12)°]. Helical supra-molecular chains along the c axis mediated by N-H?O hydrogen bonds are the most prominent feature of the crystal packing. The chains are connected into layers lying in the ac plane by weak C-H?? contacts involving two methyl-ene H atoms and an adjacent benzene ring.

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4-[3-(4-Methyl-piperidin-1-yl)propan-amido]-benzene-sulfonamide monohydrate.

Project description:In the title compound, C15H23N3O3S·H2O, the piperidine ring has a chair conformation. In the crystal, the sulfonamide mol-ecules are linked by N-H?O hydrogen bonds, forming a layer parallel to (10-1). The layers are inter-connected via N-H?Ow, Ow-H?N and Ow-H?O (w = water) hydrogen bonds, forming a three-dimensional network.

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