Dataset Information


Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.

ABSTRACT: Recent thymic emigrants (RTEs) are the youngest subset of peripheral T cells, and they differ functionally and phenotypically from the rest of the naïve T-cell pool. RTEs are present in the peripheral T-cell pool throughout life but are the most common subset of T cells in neonates and adults recovering from lymphoablation. Using a murine model to study the homeostasis of RTEs, we show that under lymphoreplete conditions, RTEs are at a competitive disadvantage to already established mature naïve (MN) T cells. This disadvantage may be caused by a defect in survival, because RTEs may transduce homeostatic signals inefficiently, and their ability to survive is enhanced with increased expression of IL-7 receptor or B-cell lymphoma 2 (Bcl-2). Conversely, under lymphopenic conditions, enhanced proliferation by RTEs allows them to out-compete their MN T-cell counterparts. These results suggest that in times of need, such as in neonates or lymphopenic adults, RTEs perform well to fill the gaps in the peripheral T-cell pool, but when the periphery already is full, many RTEs are not incorporated into the pool of recirculating lymphocytes.


PROVIDER: S-EPMC3069187 | BioStudies | 2011-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC3056472 | BioStudies
1000-01-01 | S-EPMC2773493 | BioStudies
2016-01-01 | S-EPMC5033337 | BioStudies
2017-01-01 | S-EPMC5545745 | BioStudies
2008-01-01 | S-EPMC2329696 | BioStudies
1000-01-01 | S-EPMC3631617 | BioStudies
2012-02-16 | E-GEOD-32025 | ArrayExpress
2019-01-01 | S-EPMC6409349 | BioStudies
2016-01-01 | S-EPMC4844673 | BioStudies
2011-01-01 | S-EPMC3342499 | BioStudies